A Clean Well Lighted Place - Theme and Setting Essay

Theme and Setting A clean well lighted place by Ernest Hemingway has a few themes that stand out clearly but the one theme that stands out to me is despair. According to Merriam-Webster dictionary, despair means to lose all hope or confidence. In the story, the older waiter and the old deaf man somehow share a common bond of despair. Both men are of age and like to be out, late at night, alone. Asides from the story alone, the theme of the story can be brought out by the setting. The setting contributes to the story’s theme in different ways. The setting contributes to the mood of the story, to the structure of the story, and to the lesson of the story. The cafà © represents salvation for despair which is shown through the setting of the†¦show more content†¦If the old man were to drink in that bar then the story’s mood could have been perceived in a different way. Furthermore, the setting contributes to the structure of the story, like cartilages in a human body. The cafà © c an be viewed as a workplace and also as a place of peaceful socialization. Each person deals with despair differently. Having the setting at a cafà © where it was mentioned that it was quiet help structure the story that it is neither a depressing story nor, a happy story. The two waiters who were gossiping about the old man mentioned that he had committed suicide but, he was saved. Being in a cafà © is different than rather being in a bar or anywhere else. The cafà © signifies a place for space or time, depending on the person. The old man is not trying to cure his despair but rather subdue it. The setting could have taken place anywhere but it also could have affected the structure of the story differently. For example, when the older waiter was out trying to kill time due to insomnia, he went to a bar but, it was not soothing; therefore, he went home. This proves how the setting was able to support its main structure of having a cafà © rather than a different place. Finally, the lesson of the story is that do not be impatient. The setting contributed to how the lesson of the story was delivered. The old deaf man was not harming anyone and the cafà © was not to close ‘tilShow MoreRelatedA Clean, Well-Lighted Place Essay938 Words   |  4 PagesIn â€Å"A Clean, Well-Lighted Place,† written by Ernest Hemingway conflict is clearly evident. Conflict in â€Å"A Clean, Well-Lighted Place† is determined by other elements of fiction, more importantly, characters, setting, and theme. Conflict is seen in this short story in many aspects, such as man versus man and man versus self. The characters in Hemingway’s short story add to the conflict throughout and conflict appears both between the characters and within the characters themselves. Hemingway clearlyRead MoreSymbolism In Ernest Hemingways A Clean, Well-Lighted Place1048 Words   |  5 PagesLife in a Lonely World In Ernest Hemingway’s story, â€Å"A Clean, Well-Lighted Place† the meaning could be takin in diverse way depending on how you see the story. In the story, we learn about three different characters that aren’t the same and view life completely different based off what they’ve gone through. Throughout the story we find out that two of the character can relate in a way and that the third one is selfish and only cares about himself and not others. We learn how lonely the old man isRead MoreA Clean, Well Lighted Place By Ernest Hemingway972 Words   |  4 PagesThe Pursuit of Peace and Comfort in a Clean, Well-Lighted Place Despair is an emotion that can rob one’s joy, inner peace, and eventually, life. The desire for serenity is usually sought after by a person whose life is futile and is at his or her wit’s end. That individual is usually left with no other alternative but to come to the realization that if he or she fails at his or her attempts (such as suicide) to alleviate despair, then the opportunity of finding peace and comfort is an alternativeRead MoreA Clean, Well Lighted Place By Ernest Hemingway1628 Words   |  7 PagesIn Ernest Hemingway’s â€Å"A Clean, Well-Lighted Place† the use of plot, symbolism, characters, and theme creates an intricate and complex story line. The elements of plot keep the readers engaged by guiding the reader though the story. Hemingway emphasizes on despair, loneliness, and isolation as major themes in his short story to help the reader understand the main idea. The themes represent the challenge of finding meaning in life. He also c hallenges the reader’s understanding of compassion thoughRead MoreEssay about A Clean Well Lighted Place by Ernest Hemingway641 Words   |  3 Pagesâ€Å"A Clean, Well-Lighted Place† â€Å"A Clean, Well-Lighted Place,† was written in 1933, by Ernest Hemingway. The main characters in the story are two waiters, one old, one young and an older man who is their customer in the cafà © on the evening the story takes place. There are three main elements of style portrayed in the short story, â€Å"A Clean, Well-Lighted Place.† The elements of imagery, symbolism and irony, are illustrated throughout the short story, in turn leading to the theme of despair. ImageryRead MoreErnest Hemingway Is Well-Known For Uniquely Integrating1146 Words   |  5 PagesErnest Hemingway is well-known for uniquely integrating his own experiences into his works. With each plot, he subtly weaves the elements into multiple layers of significance. His skillful use of allegory adds meaning to each story, as it allows the reader to take a step back in time and get a glimpse some of the controversies of the past. If the story were to lose its believability, the connection to the reader would be severed. Many of Hemingway’s stories allow the reader to easily grasp the superficialRead MoreCompare and Contrast of Ernest Hemmingway ´s A Clean Well Lighted Place and Sandra Cisnero ´s The House on Mango Street549 Words   |  3 Pages In Ernest Hemingway’s â€Å"A Clean, Well-Lighted Place† and Sandra Cisneros’s â€Å"The House on Mango Street†, the authors describe their feelings towards the settings in a similar way. In Hemi ngway’s short story, two waiters at a cafà © describe the differences in their lives and how they see life before them. In Cisneros’s short story, the narrator explains her past, present, and future places of residency and the impact it has in her life. Both settings in each story are different, but also very much alikeRead MoreA Clean, Well-Lighted Place. by Ernest Hemingway Essay1216 Words   |  5 Pages A Clean, Well-Lighted Place reflect Hemingways views on the loss of faith and hummanity in the world. He wrote this short story after experiencing the horrors of World War I. Hemingway, like a lot of other writers during his time, was forever affected by the war. His experiences left hime filled with doubt. Hemingway constructed a story to express his emotions of emptiness and loss that he felt as a result of the war. The story includes characters that serve as vessels for his own emotions.Read MoreA Clean, Well Lighted Place895 Words   |  4 Pages A clean, well-lighted place may be needed more by some than others on dark, lonely nights. The clean, well-lighted cafà © in Hemingway’s â€Å"A Clean, Well-Lighted Place† represents a safe place in which one can escape their troubles and loneliness that lurk in night’s darkness. In the story the characters of the older waiter and younger waiter differ substantially. They debate over the old man’s being in the cafà ©, which is an over-stayed visit to the younger waiter. The younger waiter longed for theRead MoreA Clean, Well Lighted Place By Ernest Hemingway1640 Words   |  7 Pages â€Å"A Clean, Well-Lighted Place† is possibly one of Hemingway’s most excellent short stories. It depicts the techniques of his signature writing style. The narrative is a perfect example of an initiation story, a short story that focuses on the key character that comes across a concept, encounter, practice or knowledge he never knew. The characters in his st ory are the old man, young waiter, and the old waiter. Hemingway employs a number of literary tools in the story to convey his themes of life

The Decline Of The Industrial Revolution - 971 Words

Governments are being overthrown and altered, people are viewing religion in a new way where the pope is not a pronounced powerful God, and America divided from British regulation and developed its very own nation. What do all these occurrences have in common with each other? They all ended up altering the people that existed in the world never really changed the world itself until the 1800s. During the 1800s the world’s employment forces became very enormous, food quantity was constant, raw resources were assessable, and transportation developed in to a dependable source for roaming to and from places. These things independently had no effect on the world but when all these things occur at the same time together simultaneously its influence is so strong that it changed the world and shaped in to the greatest impactful time in all of history, the Industrial Revolution. Britain started to see a huge increase in population progression throughout the years of 1750 to 1850 going from a population of roughly six mullion to twenty million individuals.(Judge 610) This population upsurge caused Britain to improve new agricultural techniques which provided British the capability to obtain a sustained food supply with fewer farmers. With a smaller amount of people becoming agriculturalists numerous quantities of people found themself unfortunate and landless. This required many people to acquire low-paid factory jobs in an urban region. With a population increase, people being forcedShow MoreRelatedThe Decline Of The Industrial Revolution1646 Words   |  7 Pageschanged the way americans lived their day to day life.All of these revolutionary changes that impacted millions of people s lives are thanks to the industrial revolution. This enormous movement known as the industrial revolution first started out in Great Britain later on spreading to the western world in the following decade. The Industrial revolution is considered a great change in human history due to the many positives it has brung to the western society in particular. For example these changesRead MoreThe Decline Of The Industrial Revolution1462 Words   |  6 Pagesbeing due to Britain s culture, institutions or just luck. This essay will argue for the abundance of cheap coal and a ready workforce and industrial capitalism as major factors in the industrial revolution. The industrial revolution was characterised by a slow and steady continuous economic growth which has begun in the 15th century. The industrial revolution did not see a sudden rise in Britain s GDP, in fact there were large growths in only some sectors, but it was a period marked by profoundRead MoreThe Decline Of The Industrial Revolution Essay2234 Words   |  9 PagesDuring the end of the eighteenth century a revolution unlike any seen by American swept America introducing the civilization to mo dern machinery and transition to a new manufacturing process. The Industrial Revolution is a â€Å"name given to movement in which machines changed people’s way of life as well as their methods.† The origin of the movement started from The Great Britain which affected the entire manufacturing process and life of American. The revolution did not only bring changes to manufacturingRead MoreThe Decline Of The Industrial Revolution1554 Words   |  7 PagesThe industrial revolution is a rapid development of industry that happened in Britain in the late 18th and 19th centuries. It was characterized by the development of machinery, the growth of factories and the large production of manufactured goods. Between the end of the Civil War and the early twentieth century, the United States experienced one of the most significant economic technologies from Britain to the United States and founded the first U.S cotton mill in Beverly, Massachusetts. In additionRead MoreEffects of the Industrial Revolution on Slavery Essays957 Words   |  4 PagesEffects of the Industrial Revolution on Slavery The Industrial Revolution started in Britain, where population was sky rocketing and demand for goods was increasing. This higher demand forced innovators and scientists to invent machines that would make production much faster than their old ways. Before the push for new technology, goods were being produced through the putting-out system: one where a manufacturer would make part of the product, send it out for someone to finish it, then put it onRead MoreThe Difference Of Interpretation On Coal Industry865 Words   |  4 Pagesgreat era could bring the honor of history for people. Especially for the industrial past, it is easier to motivate the nostalgic impulse. In Britain, coal resource not only influenced the development of industry and technology, but also improved people’s daily life and their working life in the past. According to research the history of Britain, there are three vital periods about coal industry including industrial revolution in Britain, Victorian Britain and de-industrialization in the UK that mightRead MoreThe Positives And Cons Of The Industrial Revolution835 Words   |  4 PagesIs the Industrial Revolution as Good as We Think It Is? Bill Gates once said, â€Å"If you go back to 1800, everybody was poor. I mean everybody. The Industrial Revolution kicked in, and a lot of countries benefited, but by no means everyone.† The Industrial Revolution was a period in the 18th century led by Great Britain that had a major influence in agriculture, scientific studies, manufacturing, and transportation. As said by Bill Gates, even though the Industrial Revolution benefited many partiesRead MoreOver the decades, enclosures had been occurring in England and eventually became common in the1100 Words   |  5 Pagestried to make innovations that would benefit them and their families. However, these landowners knew they couldn’t be prejudice against the poor. Peasants worked on the common lands so the landowners knew it would affect them greatly. Population decline was the main concern that landlords had. Despite their concerns, they still proceeded with enclosures because they believed that the benefits would outweigh the problems. According to Lacey Baldwin Smith, peasants held their land â€Å"either by copyholdRead More The Industrial Revolution Essay example985 Words   |  4 PagesPeter Stearns claims that the industrial revolution was an intensely human experience. What initially arose as scientific advancements in metallurgy and machine building, the industrial revolution period saw a redefinition of life as a whole. As industry changed, human life began to adapt. Work life was drastically changed which, in turn, resulted in family life being affected. As is human nature, major change was met with great resistant. Ultimately, the most successful people during the transitionRead MoreExploitation of Children during the Industrial Revolution in Great Britain1867 Words   |  7 Pagesas the Industrial Revolution. It brought a surge of technological innovations, an increase in production, more world trade, and a rise in urban population. One of the most controversial and widel y debated issues until today among historians is the use of child labor. Despite that this era led to massive economic growth and social development, it violated women’s rights and exploited children. The purpose of this paper is to examine the exploitation of children during the Industrial Revolution in Great

Portrayal of Utopia in The Tempest Essay example - 1652 Words

Portrayal of Utopia in The Tempest In The Tempest, Shakespeare allows the audience to appreciate the possibilities of utopian society and whatever this may posses. Being the good, and bad so that they can see that problems can arise in such a society. The Tempest can be thus seen as a window into the dimensions of utopian societies. While his characters take on the role of the leaders of the utopian societies, Shakespeare uses his creation to portray the social questions and beliefs of society of how a utopian environment should be. Essential to the discussion of this aspect of The Tempest is the definition of a Utopia. For different characters this utopia means different things. First of all and maybe most†¦show more content†¦However simultaneously the view of Antonios utopia is the picture of evil. His own evil intentions and deceitful gain of power fuelled by ego centric views, were what people of that time would have labeled a dystopia, the opposite of a utopia. Specifically referring to Mirandas utopia we can see how she takes a rather naà ¯ve view on what a Utopian society should hold. As aforementioned all her life she has been isolated on the island seeing no-one but her father as well as his slaves Ariel and Caliban, and therefore upon seeing other beings she is amazed and overcome by her new discovery. In seeing the demise of the ship she claims ‘Had I been any God of power, I would have sunk the sea within earth or ere’, this isolates her desperation in saving something so magical and indeed alien to her. In the closing scene Miranda also exclaims rather naively; ‘How beauteous mankind is! O brave new world/That has such people in’t’. The irony is fuelled by how this whole scenario has not been based on truth or scientific discovery as fuelled by Enlightenment debate but rather an illusion and destructive actions coined by her father Prospero. Miranda’s role in the play, along with Ferdinand is to unite enemies (Prospero Alonso), and this links in to Ferdinands utopia which represents true love (as it has passed Prosperos tests). Ferdinand therefore finds a utopia on the island, because in marrying Miranda his lifeShow MoreRelated Portrayal of Utopia in The Tempest by William Shakespeare Essay examples1227 Words   |  5 PagesUtopia in The Tempest In The Tempest, Shakespeare allows the audience to appreciate the possibilities of utopian society, the good, and bad, so that they can understand the problems that the pursuit of a utopian environment may cause. The Tempest is a window into the dimensions of utopian societies. Shakespeares play portrays the good and the evil sides of the perfect life. While his characters take on the role of the leaders of the utopian societies, Shakespeare portrays the socialRead More Conflict and Harmony in The Tempest Essay1390 Words   |  6 PagesConflict and Harmony in The Tempest   Ã‚  Ã‚   William Shakespeare describes a utopic world saturated with supernatural images and ideas which works to create the mysterious island where The Tempest takes place.   This is one of Shakespeares best examples of how a natural harmony reveals itself through the actions of discourse and confusion.   To illustrate this idea best one must examine the historical context upon which The Tempest is based.   Because this play was published in the early 1600sRead MoreWilliam Shakespeare s Tragicomedy The Tempest1935 Words   |  8 PagesLiterary texts rarely stand alone, frequently including elements from other influences. William Shakespeare’s tragicomedy The Tempest (c:1611) is a play that uses intertextuality to enhance ideas about natural order. Banished to an island, Prospero, the rightful Duke of Milan, conjures up a tempest that brings him his usurping brother, Antonio in an attempt to restore his Dukedom. The play’s amalgamation of tragicomedy and the pastoral genre allows Shakespeare to warn his audience about unbalanceRead MoreVinegar Tom: More Than Just a History Play2652 Words   |  11 PagesChurchill’s plays display a preoccupation with political possibility and reveal traces of Utopian desire (Adisehiah Utopian Space). Her 1970s plays, in particular, intersect with and reflect a cultural context that produced rejuvenated engagements with Utopia (Adisehiah Utopian Space). The theatre groups Joint Stock and Monstrous Regiment, who performed the original productions of her history plays Light Shining in Buckinghamshire (1976) and Vinegar Tom (1976) (Constanakis 159), were additionally committed

Two Speeches by Martin Luther King Jr. - 671 Words

Martin Luther King Jr. has had many sensational speeches. The successes presented in the two excerpts can be used as examples for success towards other speeches. In speeches ethos is used to reach out to the audience like Martin Luther King Jr. does. Professor Brown defines ethos as voice of credibility. Martin Luther King Jr. during his two excerpts uses pathos. Professor Brown defines pathos as passion, and narrative. In most speeches Martin Luther King Jr. uses logic, logos to addresses the audience into understanding the meanings. Professor Brown defines logos as logic. Logic is supported by science, induction and deduction. Excerpt one is Martin Luther King Jr. talking to Africans about their freedoms and starts the speech by addressing the wrongs of slavery. Excerpt one is located in Crawfordville, Georgia. The purpose of this excerpt is to get the African Americans that Martin Luther King Jr. is giving his speech to, to get energized. Martin Luther King Jr. wants the crowd to help him stop the racism going on around them. The way that Martin Luther King Jr. approaches the audience at Crawfordville, Georgia is not to use big words to confuse them but to come out and tell them what is happening around them and that it needs to be stopped. Martin Luther King Jr. says â€Å"Our four parents labored right around here for two centuries without wages. They made cotton king they built the homes of their masters and oppressed in the midst in the most humiliating andShow MoreRelated Martin Luther King And Patrick Henry: Cry For Freedom Essay545 Words   |  3 Pages Martin Luther King and Patrick Henry: Cry for Freedom Although Patrick Henry and Martin Luther King, Jr. are both skilled orators and use similar rhetorical devices to appeal to their audiences, they call for freedom for two totally different kinds of people. Both Patrick Henry and Martin Luther King, Jr. show their strengths as speakers through their use of these rhetorical devices. Among these are parallelism, allusions, metaphors, and rhetorical questions. Both speakers use theseRead MoreDr. Martin Luther King Jr., A Political Icon Essay1441 Words   |  6 Pagesbecause they and their accomplishments have forever changed society and the world. Dr. Martin Luther King Jr. was one of those individuals. Martin Luther Kings contributions to history place him in this inimitable position. One of the great figures in the march of human history, Martin Luther King Jr., like Gandhi before him, lived by a heroic credo of non-violence. More than two decades since his death, Martin Luther King ideas; his call for racial equality, his faith in the ultimate triumph of justiceRead MoreThe Beliefs of Martin Luther King Jr. versus Malcolm X Essay1208 Words   |  5 PagesBeliefs of Martin Luther King Jr. versus Malcolm X â€Å"I have a dream, that one day little black boys and black girls will join hands with little white boys and white girls and walk together as sister and brother.† (de Kay 75)†¦Martin Luther King Jr. During the past century, the United States of America has wresled with the problem of inequality between black and white people. Two influential people who helped to combat racism and the inequality of man were Martin Luther King Jr. and MalcolmRead MoreMartin Luther King, Speech Research1572 Words   |  7 PagesIntroduction- English, speech I have a dream was one of the most powerful and influential speeches of all time, it not only created the realisation that the Negro was not free, it persuaded that of white people to make a change for the benefit of the African Americans. The African American civil rights movement was creeping forward but two individuals created a greater atmosphere for the reinforcement of the movement, sure William Wilberforce abolished the slave trade for Britain in 1807, and thatRead MoreCompare and Contrast the Work of Martin Luther King Jr Malcolm X923 Words   |  4 PagesMartin Luther King Jr. and Malcolm X were very significant during the Civil Rights Movement. Both were excellent speakers and shared one goal but had two different ways of resolving it. Martin Luther King Jr. chose to resolve the issues by using non-violence to create equality amongst all races to accomplish the goal. Malcolm X also wanted to decrease discrimination and get of segregation but by using another tactic to successfully accomplish the similar goal. The backgrounds of both men wereRead MoreDifferences Between Martin Luther King and Malcolm X Essay805 Words   |  4 PagesDuring the 1960’s Dr. Martin Luther King, Jr. and Malcolm X represented two sides of the Civil Rights Movement. Speaking to all of humanity, Dr. King made these famous peaceful words, â€Å"I have a dream, a dream that one day this nation will rise up and live out the true meaning of its creed: â€Å"We hold these truths to be self-evident, that all men are created equal† (King, 1963, para 10). Malcolm X spoke of a violent revolution by claiming, â€Å"If it’s necessary to form a Black Nationalist army, we’llRead MoreThe Art of Persuassion and Speeches Essay1089 Words   |  5 Pagesthousands of people were affected by the famous speech made by Martin Luther King Jr. This speech was titled â€Å"I Have A Dream†. (Martin Luther King Jr.) It takes much skill to make this type of i mpact on this many people. But Martin Luther King Jr. was not the only person capable of persuading a crowd. In the book â€Å"Animal Farm†. (George Orwell) Squealer and Napoleon persuaded the whole farm to be part of a series of malicious activities. In speeches created and presented by Malcolm X you will find similarRead MoreThe Dream and the Ballot or the Bullet1038 Words   |  5 PagesDeclaration of Independence was far from a reality. Martin Luther King Jr., a Baptist minister delivered his famous speech â€Å"I Have a Dream† August 28th, 1963 in Washington DC. He is credited with mobilizing supporters of desegregation and prompted the 1964 Civil Rights Act. Malcolm X delivered his famous speech â€Å"The Ballot or the Bullet† on April 12th, 1964 in Detroit. Though many people say Malcolm X was violent he made many good key points. Martin Luther King Jr. and Malcolm X both helped encourage AfricanRead MoreMartin Luther King Jr. and Malcolm X1491 Words   |  6 Pagessprouted from the influence of this period. Two strong leaders from this era were Martin Luther King Jr. and Malcolm X. Martin Luther King Jr. made a bigger impact on the population than Malcolm X because of his speeches, beliefs, direct and peaceful activities, and the effect his death had on the population. Martin Luther King Jr.’s belief was that people of all colors, including both blacks and whites, could live in eternal peace and equality. King believed that â€Å"an unjust law is no law at all†Read MoreMartin Luther King Jr.: An American Hero1193 Words   |  5 Pagesreconstruct society. Of these people, Martin Luther King Jr., an African American pastor from Atlanta, Georgia, was one of the strongest civil rights activists in American history. He successfully fought against the status quo and as a result, he revolutionized American society. Martin Luther King Jr. was born in Atlanta, Georgia in 1929 and just like his father and grandfather, King became a pastor. He was a very peaceful and intelligent man. In fact, he skipped two grades during high school and entered

The Tried and True Method for Research Paper Writing Services in Step by Step Detail

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Zlateh the Goat free essay sample

Mother+Aaron+Family-(Mother take two slices of bread, Aaron takes it and then family gets off the stage) Narrator-Aaron is now off to his journey to the town and hes supposed to spend the night at the Butchers place. Zlateh-(appear in the stage) Aaron+Zlateh-(Walk.. just keep on walking,in circles or squares,whatever ) Narrator-Zlateh trusted humans, but he had been led to a mysterious track, and somehow seems astonished. Zlateh-(Bahh ) Narrator-As Zlateh and Aaron keep walking in the direction of the town, they relize that the sky is getting really dark and snow starts falling. Prop-(1:Hold the clouds 2:Throw a little bit of snow onto them ) Narrator-As what is happening is that they relize a storm is heading out towards them because the wind blows loudly whistling, and the snow hitting on them harder and their fright occurs. Prop-(Huiying whistlee wind noises )(Someone use a fan, and fan Zlateh and Aaron as they were being blown by the wind) Zlateh-Bahhhhhh. We will write a custom essay sample on Zlateh the Goat or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Bahhhhh. Narrator-The storm is now wildd, and the snoww is also crazilyy falling, it now gets harder and harder for them to walkk, and causes Aaron to collapse. Aaron-(Pretend the road is really hard to walk and pretend to tug on Zlatehs Rope really hard, then fall. then pick your self up) Narrator-Zlateh wished to be home by the time, and so she felt betrayed by her fellow human beings.. Aaron-(pray.. )Dear God, I pray that Zlateh, this innocent animal, and I will be safe through this storm. Narrator- As they keep on walking, they see a pile of hay, and irresistibly, Aaron took Zlateh into the Hay with him, and of course, Zlateh was hungry, so he gobble up some of the hay, and Aaron ate some of his bread. Zlateh+Aaron-(get into the hay room when Narrator says Aaron took Zlateh into the Hay) Zlateh-(eat the hayy, then lay down) Aaron-(eat the bread) Narrator-As you see, Zlatehs utters were full. Aaron-(Stare at Zlatehs utters) Narrator-Aaron was still hungry, and since Zlatehs utters were full, Aaron drunk some milk. :S: Aaron-(drink milk out of Zlatehs utters by squeezing them while narrator talks, keep on doing it until the next Bahh after Narrator talks) Narrator-As the days passed, they did the same to survive, and soon, Aaron treated Zlateh as a sibling, and loved her very much. Aaron had no one to talk to, and Zlateh was the only one that was there, so. Aaron talked to Zlateh to share his thoughts and feelings Aaron-Zlateh, what do you think about what had happened to us. Zlateh-Bahhh. Aaron-If we hadnt found this stack of hay, we would both be frozen stiff by now. Zlateh-Bahhh. Aaron-If the snow keeps on falling like this, we would have to stay in here for many many days. Zlateh-Bahhh. Aaron-What does Bahh mean, you better speak up clearly. Zlateh-Bahhh. Bahh.. Aaron-I know your trying but you cant so let it be Bahh.. Zlateh-Bahhh. Aaron-I know you understand me even if you cant speak, but I need you, and you need me right. Zlateh-Bahhh.. Aaron-(Yawnn) I think its late, make pillow out of some hay. (fall asleep) Zlateh-Bahh. (fall asleep) Narrator-They slept and slept. until they felt energized. and their next day starts.. Aaron-(Wake up, open your eyes, then yawnn. ) Narrator-Aaron had no idea either it was day or night, the window was covered by snoww, and he couldnt reach out to the window, but when he peeked outside, it was dark, he had no way to identify is it day or night. :S: Aaron-(look at the window, then use a stick to poke out the window) Prop-(Throw lots of snow when Aaron peeks out)(Someone whistle like the wind) Zlateh-(Wake up) Bahh. Aaron-I know that your language is only one word, but it means alot, Zlateh. Zlateh-Bahhh. Aaron-I know that this is already perfect, we have to accept what god gives us, heat, cold, hunger, satisfaction, light and darkness. Its just life. Zlateh-Bahhh. Prop-(make a tummy rumble sound for Aaron) Aaron-Oh, I guess Im hungry, I guess I dont mind taking some of your milkk.. (squeeze Zlatehs utters and preten to drink milk) Narrator-For three days, Aaron and Zlateh stayed in the haystack, and of course, Aaron had always loved Zlateh, but in these three days, he loved her more and more. Zlateh fed Aaron with milk and help him keep warm and also comforted him with patience while Aaron told Zlateh many stories, and Zlateh always listened. Aaron-(pat Zlateh head) Zlateh-(lick Aaron face)Bahh.. Aaron+Zlateh-(fall asleep) Narrator-Aaron new that the actions and words werent much, but he known it meant I Love you. Narrator-The snow fell for three days already and those days were silent, all that was heard were the wind howling all day. Those days mostly included sleeping, they slept all night, and a good part of the day. As for Aaron, his dreams were all about warm weather, he dreamed of green fields, trees covered with blossoms, clear brooks, and singing birds. Aaron-(Wake up)Zlateh, the snow stopped!!!! Zlateh-Bahhh Narrator-The snow stopped falling, and the storm was over, but Aaron didnt dare to find his way home in the darkness. The sky was becoming clear, and the shone. Prop-(Show the moon) Aaron-(Aaron, Dig you way out of the hay, then look around like your looking around the world) Narrator-They stayed and slept in the haystack until the next day and. Prop-(ring bells) Aaron-Zlateh, you hear bells ringing!!! Zlateh-Bahhh. Aaron-(pushes out the haystack) Aaron-Hi peasant, may you point out the way to the town. Peasant-(enter stage with sled) Peasant on sleigh-Im sorry little boy, I dont know the way there, but if you go this way, there will be a village.. Peasant-(off stage with sled) Narrator-While Aaron and Zlateh are following the peasants directions to get back to the village, Aarons family and their neighbors had searched for the Aaron and Zlateh but they found no trace of them during the storm. They feared that they were lost. :s: Mother+Father+Neighbor-(eneter the stage with paper) Mother+Father+Neighbors-(walk all around asking)did you see a little boy and a goat anywhere? Neighbor-(off the stage) Mother+Sisters-(cry ) Father-(stay sad and gloomy) Neighbor-(enter stage) Alert Neighbor-(Runn to family)Hey, Hey, Aaron and Zlateh are coming up the road!! Aaron and Zlateh are coming up the road!! Neighbor-(off stage) Family-(smilee)Your backk, Im so glad that your okay!!! Narrator-Aaron then shares the way he survived during the storm. Aaron-(pretend to explain to the family about how they survive storm) Sisters-(hug Zlateh, then feed Zlateh some chopped carrots) Zlateh-(Gobble up all the carrots) On stage people-(Keep on doing same action until told to do somthing else) Narrator- No-one ever thought of selling Zlateh anymore for what he has done for the family. Narrator-They were glad the cold weather has finally set in. The villagers lined up one by one asking Reuven the furrier for his services. Extras-(enter stage) Reuven+Extras-(have the extras line up in front of you, and then I want you to measue the extras, and preten you are going to make them their clothing) Narrator when Hanukkah came, y mother made pancakes every evening, and Zlateh even got her portion. And of course Zlateh had a Pen, but he always knocked his horns on the door of the Kitchen, and they always let him in Reuven+extras-(off stage) Mother-(make pancakes) Kids-(play with dreidal) Zlateh-(watch flickering lights) Narrator-The kids spent Hannukah playing the Dreidal, and Zlateh watched them, and the flickering lights of the Hannukah candles. And once in a while Aaron would ask Zlateh.. Aaron-Remember the three days we spent together? Zlateh-Bahh.. Everyone-(Bow) Hope you enjoyed the play, Zlateh the goat. (Then everyone off stage) The End..a

Strategies In Cancer Chemotherapy Cytarabine An Assessment Biology Essay Example For Students

Strategies In Cancer Chemotherapy Cytarabine An Assessment Biology Essay Cytarabine besides known as ( Ara-C ) is an endovenous chemotherapeutic drug normally used to handle acute myelocytic leukaemia. This is a malignant neoplastic disease situated on the myeloid line of blood cells, characterised by the rapid growing of unnatural white blood cells that accumulate in the bone marrow. Ara-C onslaughts both cancerous and non-cancerous cells as they undergo DNA synthesis. The mechanism of action of each drug is multifaceted but chiefly involves suppressing DNA synthesis. Ara-C is transported into the cell where it is activated by phosphorylation. Deoxyribonucleic acid reproduction occurs at the taking strand of the reproduction fork by add-on of the bases in the 5? A ; gt ; 3? way to organize one new girl strand. The 2nd girl strand consequences from reproduction of the lagging Deoxyribonucleic acid strand at the reproduction fork where the lagging strand replicates discontinuously and requires synthesis of a primer. Okazaki fragments are intermediates created from the lagging strand as a consequence. The rate of reproduction for atomic DNA is frequently elevated in malignant cells, peculiarly in aggressive tumors, comparative to environing healthy tissues. Disruption of DNA reproduction of malignant cells inhibits tumour growing and enlargement. Therefore interrupting DNA synthesis preferentially targets malignant cells. Ara-C feats this mechanism to stamp down tumour growing. Ara-C can make this because it is an parallel of cytidine and becomes misincorporated into DNA during reproduction alternatively of cytidine doing changes in the construction, stableness and protein adhering features of the girl DNA. Cytarabine inhibits DNA elongation, with suppression happening preponderantly at the lagging strand of the reproduction fork. It is besides an S-phase-specific agent upon activation and is a competitory inhibitor of DNA polymerase alpha and beta. Inhibition of DNA synthesis through premature concatenation expiration, competitory suppression and the inability of DNA polymerases to adhere adequately to DNA girl strands causes malignant cell programmed cell death. Drug Discovery: Cytarabine i.e. Ara-C was derived from cognition gained from the close scrutiny of bioactive Marine nucleosides, found in the marine environment. Cytarabine is an illustration of a marine-derived drug. The drug was foremost discovered in 1945 by a chemist named Werner Bergmann who collected sponges from the shallow Waterss from Elliot Key, Florida. This unidentified species called Cryptotethia crypta named by Dr. M. W. De Laubenfels discovered more of these sponges off the Islands in the Bahamas. Upon closer scrutiny by the manner of boiling the sponges in propanone in a Soxhlet extractor setup, Bergmann observed crystalline stuff separated from the propanone. This stray stuff was found to be a constituent in a mixture of drugs used for the intervention for acute lymphoblastic leukaemia. UV analysis in the signifier of an soaking up spectrum that was similar to the construction of the nucleotide thymidine. This new compound similar to thymidine was named spongothymidine since the co mpound was derived from sponges. This led to the find that a nucleoside has biological activity. The subsequent detonation of compounds and these finds led to the designation of a close parallel, C arabinoside, as powerful antileukemic agent and was later commercialised by Upjohn ( now known as Pharmacia ) as Ara-C. Other near compounds such as Ara-A were synthesised and commercialised by Burroughs Wellcome ( now GSK ) . Computer assisted drug design can be used to happen the chief active binding sites. These adhering sites correspondent to deoxycytidine place important bindings to functional groups besides present within DNA in cancerous cells, i.e. the mark enzymes involved in DNA synthesis. Computer assisted drug design allows the drug design to be similar in construction to cytidine i.e. be a cytidine parallel. .ucd6731d3378c12d53f9033b05dbcb0ff , .ucd6731d3378c12d53f9033b05dbcb0ff .postImageUrl , .ucd6731d3378c12d53f9033b05dbcb0ff .centered-text-area { min-height: 80px; position: relative; } .ucd6731d3378c12d53f9033b05dbcb0ff , .ucd6731d3378c12d53f9033b05dbcb0ff:hover , .ucd6731d3378c12d53f9033b05dbcb0ff:visited , .ucd6731d3378c12d53f9033b05dbcb0ff:active { border:0!important; } .ucd6731d3378c12d53f9033b05dbcb0ff .clearfix:after { content: ""; display: table; clear: both; } .ucd6731d3378c12d53f9033b05dbcb0ff { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ucd6731d3378c12d53f9033b05dbcb0ff:active , .ucd6731d3378c12d53f9033b05dbcb0ff:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ucd6731d3378c12d53f9033b05dbcb0ff .centered-text-area { width: 100%; position: relative ; } .ucd6731d3378c12d53f9033b05dbcb0ff .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ucd6731d3378c12d53f9033b05dbcb0ff .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ucd6731d3378c12d53f9033b05dbcb0ff .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ucd6731d3378c12d53f9033b05dbcb0ff:hover .ctaButton { background-color: #34495E!important; } .ucd6731d3378c12d53f9033b05dbcb0ff .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ucd6731d3378c12d53f9033b05dbcb0ff .ucd6731d3378c12d53f9033b05dbcb0ff-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ucd6731d3378c12d53f9033b05dbcb0ff:after { content: ""; display: block; clear: both; } READ: Pearl Harbor Conspiracy EssayActive site volumes of dCKc and dCKm were calculated by bring forthing the adhering pockets of the enzymes. These of which are similar to the construction of Ara-C: Drug Synthesis: It is possible to synthesize cytarabine, ara-C utilizing the undermentioned synthesis path. This path is besides used and established for the synthesis of ara-AC, an ara-C derived function. This derivative contains an excess N heteroatom within the ring. The first measure in the synthesis path involves hydrogenation of the initial compound utilizing H over a palladium accelerator. This is an illustration of a heterogeneous accelerator that provides a surface for the reactant molecules. The reactant is placed in an ethanolic H chloride solution taking to the decrease of the dual bond. The following phase in the synthesis path is intervention of the 2nd compound at room temperature with bis-trimethylsilyl-trifluoroacetamide ( BFTFA ) in acetonitrile solution produced the pentakis-trimethylsilyl derived function. This is allowed to reflux for several hours until full transition to the last merchandise ara-C is completed. Vaporization of the reaction solution produces syrup where it is boiled in methyl alcohol to take trimethylsilyl groups by solvolysis. Ara-C is so crystallised from the solution as a consequence. Drug Selectivity, authority and SAR: Cytarabine chief mark i.e. selectivity is indistinguishable to that of the nucleoside deoxycytidine due to the fact it is a nucleoside parallel. It acts chiefly as a competitory inhibitor to cytidine triphosphate. Ara-C is metabolised in vivo to ara-CTP and competes with CTP during DNA synthesis with Deoxyribonucleic acid polymerases both alpha and beta. To exercise its cytoxic effects, cytarabine is converted ab initio to the 5-phosphate via rate restricting phosphorylation catalyzed by deoxycytidine kinase ( dCK ) in tumor cells and so finally to its 5-triphosphate ara-CTP. Ara-CTP presumably Acts of the Apostless both by suppressing the binding of 2-deoxycytidine triphosphate to DNA polymerase and by incorporation into stretching DNA strands, ensuing in faulty ligation or uncomplete synthesis of Deoxyribonucleic acid fragments and finally cell decease programmed cell death. Targets of this chemotherapeutic drug besides include adhering sites of the correspondent molecule cytidine. The authority of the ara-C is nevertheless limited in its public-service corporation as an anti-cancer nucleoside because of hapless intracellular conveyance features. Besides it has a weak activity as a substrate for tumor cell kinases. Therefore the development of drug opposition as a consequence from reduced nucleoside kinase activity as lowered the efficaciousness of this agent. Tumour cells deficient in dCK ( deoxycytidine kinase ) are extremely immune to cytarabine, so intramolecular bringing of ara-CMP might be expected to besiege opposition in these cells. Ara-C and similar nucleoside parallels enter cells via specific transporters which are indispensable to ara-C cytotoxicity in human tumor cells. Hence nucleoside transporter lacking cells are extremely immune to cytarabine. Therefore to turn to this job a prodrug of cytarabine is synthesised and used alternatively which can spread passively into cells where it is metabolised into an active signifier, i.e. intracellular activation, and therefore overcomes resistance jobs such as restricting nucleoside transporters. An illustration of a prodrug is cytarabine phosphoramidate. An in-vitro survey assay on tumor malignant lymphoid cells indicated the drug inhibited cell growing up to 50 % of the control value, where the stock drug was prepared in absolute ethyl alcohol. This process was undertaken in a 72h incubation period where information recorded fitted a sigmoid curve and the consequences were expressed as the IC50. Other surveies in vivo conducted on mice with grafted human malignant neoplastic diseases of different types. Cytarabine is effectual against malignant neoplastic disease cells within mice B and mice D. It has some authority against malignant neoplastic disease cells C but opposition develops as a consequence and it is uneffective against A. The structure-activity relationship, i.e. the relationship between the chemical construction of the molecule and its biological activity is the biological responsiveness with G in DNA reproduction, correspondent to cytidine guanine interactions. The SAR constituents of cytarabine are therefore as follows and derived from cytidine. Besides similar in SAR and responsiveness is gemcitabine which works in an tantamount manner to both cytarabine and cytidine but marks lung malignant neoplastic disease, pancreatic malignant neoplastic disease and chest malignant neoplastic disease cells. .u93a20a8093ad6771a70f021d605269be , .u93a20a8093ad6771a70f021d605269be .postImageUrl , .u93a20a8093ad6771a70f021d605269be .centered-text-area { min-height: 80px; position: relative; } .u93a20a8093ad6771a70f021d605269be , .u93a20a8093ad6771a70f021d605269be:hover , .u93a20a8093ad6771a70f021d605269be:visited , .u93a20a8093ad6771a70f021d605269be:active { border:0!important; } .u93a20a8093ad6771a70f021d605269be .clearfix:after { content: ""; display: table; clear: both; } .u93a20a8093ad6771a70f021d605269be { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u93a20a8093ad6771a70f021d605269be:active , .u93a20a8093ad6771a70f021d605269be:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u93a20a8093ad6771a70f021d605269be .centered-text-area { width: 100%; position: relative ; } .u93a20a8093ad6771a70f021d605269be .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u93a20a8093ad6771a70f021d605269be .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u93a20a8093ad6771a70f021d605269be .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u93a20a8093ad6771a70f021d605269be:hover .ctaButton { background-color: #34495E!important; } .u93a20a8093ad6771a70f021d605269be .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u93a20a8093ad6771a70f021d605269be .u93a20a8093ad6771a70f021d605269be-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u93a20a8093ad6771a70f021d605269be:after { content: ""; display: block; clear: both; } READ: Roots of AntiSemitism EssayAn of import portion of ara-C in conformity to its structural activity relationship lies on the phosphorylation as discussed earlier for this compound ; a close analogy is cytidine and similar in construction gemcitabine phosphorylation by dCK. This SAR constituent is on the OH group to bottom left of the O heteratom in the ring, which becomes phosphorylated.